Mammalian cells contain a second nucleocytoplasmic hexosaminidase
نویسندگان
چکیده
منابع مشابه
Mechanism of Human Nucleocytoplasmic Hexosaminidase D
Mammalian β-hexosaminidases have been shown to play essential roles in cellular physiology and health. These enzymes are responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. One of these β-hexosaminidases, hexosaminidase D (HexD), encoded by the HEXDC gene, has received little attention. No mechanistic stud...
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KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1 subunits in IKs channels has been an issue of ongoing debate. Here, we use single-molecule spectroscopy to demonstrate that surface IKs channels with human subunits contain two E1 and four Q1 subunits. This stoichiometry does not vary. Thus, I...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2009
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20081630